Hyls1 | HYLS1, centriolar and ciliogenesis associated

GeneMGI:1924082Synonyms: hydrolethalus syndrome 1, 3010015K02Rik

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Skeleton Mortality/aging Cardiovascular system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



long tibia	1 supporting dataset	Hyls1^em1(IMPC)Tcp	heterozygote	Early adult	3.73x10^-5
decreased prepulse inhibition	2 supporting datasets	Hyls1^em1(IMPC)Tcp	heterozygote	Early adult	1.28x10^-5
abnormal heart looping	1 supporting dataset	Hyls1^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Hyls1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Hyls1^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
prolonged PQ interval	1 supporting dataset	Hyls1^em1(IMPC)Tcp	heterozygote	Early adult	8.98x10^-5
abnormal embryo turning	1 supporting dataset	Hyls1^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
decreased circulating total protein level	1 supporting dataset	Hyls1^em1(IMPC)Tcp	heterozygote	Early adult	9.14x10^-5
embryonic growth retardation	1 supporting dataset	Hyls1^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Hyls1^em1(IMPC)Tcp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hyls1.

Associated images

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Histopathology

There is no histopathology data found for Hyls1.

IMPC related publications

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External links

No external links available for Hyls1.

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*Hyls1^em1(IMPC)Tcp*	Intra-exon deletion	‌	mouse
*Hyls1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Hyls1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Hyls1^{tm461283(L1L2_GT2_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Hyls1^{tm4a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Hyls1^{tm5a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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