Cenpo | centromere protein O

GeneMGI:1923800Synonyms: 8430427C03Rik, D12Ertd482e, +1 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased heart weight	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.74x10^-8
decreased circulating glucose level	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.41x10^-6
hyperactivity	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	5.44x10^-5
abnormal lens morphology	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	3.81x10^-5
decreased circulating calcium level	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	4.11x10^-8
decreased circulating triglyceride level	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.73x10^-5
decreased circulating free fatty acids level	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	3.15x10^-8
decreased circulating HDL cholesterol level	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.31x10^-9
decreased blood urea nitrogen level	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	heterozygote	Early adult	1.79x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Cenpo^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cenpo.

Associated images

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Histopathology

There is no histopathology data found for Cenpo.

IMPC related publications

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External links

No external links available for Cenpo.

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*Cenpo^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cenpo^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cenpo^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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