Gpr22 | G protein-coupled receptor 22

GeneMGI:1920260Synonyms: 2900068K05Rik

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased hemoglobin content	1 supporting dataset	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.08x10^-5
decreased total body fat amount	2 supporting datasets	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.9x10^-6
hyperactivity	7 supporting datasets	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.05x10^-10
abnormal gait	1 supporting dataset	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.91x10^-5
increased lean body mass	2 supporting datasets	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.09x10^-5
increased circulating creatinine level	1 supporting dataset	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.06x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.72x10^-12
increased circulating alanine transaminase level	1 supporting dataset	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.19x10^-9
decreased hematocrit	1 supporting dataset	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.97x10^-5
increased circulating phosphate level	1 supporting dataset	Gpr22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.11x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gpr22.

Associated images

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Histopathology

There is no histopathology data found for Gpr22.

IMPC related publications

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External links

No external links available for Gpr22.

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*Gpr22^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gpr22^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gpr22^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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