Tdp1 | tyrosyl-DNA phosphodiesterase 1

GeneMGI:1920036Synonyms: 4921509N21Rik, SCAN1, +3 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Immune system Hematopoietic system Behavior/neurological

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased mean corpuscular volume	1 supporting dataset	Tdp1^em1(IMPC)Tcp	homozygote	Early adult	5.94x10^-6
enlarged lymph nodes	1 supporting dataset	Tdp1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Tdp1^em1(IMPC)Tcp	homozygote	Early adult	8.73x10^-5
decreased exploration in new environment	1 supporting dataset	Tdp1^em1(IMPC)Tcp	homozygote	Early adult	2.92x10^-5
increased red blood cell distribution width	1 supporting dataset	Tdp1^em1(IMPC)Tcp	homozygote	Early adult	4.58x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tdp1.

Associated images

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Histopathology

There is no histopathology data found for Tdp1.

IMPC related publications

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External links

No external links available for Tdp1.

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*Tdp1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Tdp1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tdp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tdp1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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