Ppp6c | protein phosphatase 6, catalytic subunit

GeneMGI:1915107Synonyms: 2310003C10Rik

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Mortality/aging

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Ppp6c^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	1 supporting dataset	Ppp6c^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.6x10^-5
increased fasting circulating glucose level	1 supporting dataset	Ppp6c^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.02x10^-6
short tibia	1 supporting dataset	Ppp6c^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.88x10^-5
abnormal locomotor behavior	1 supporting dataset	Ppp6c^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.32x10^-5
increased mean corpuscular volume	1 supporting dataset	Ppp6c^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.5x10^-5
decreased blood urea nitrogen level	1 supporting dataset	Ppp6c^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.65x10^-5
abnormal vocalization	1 supporting dataset	Ppp6c^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.04x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppp6c.

Associated images

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Histopathology

There is no histopathology data found for Ppp6c.

IMPC related publications

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External links

No external links available for Ppp6c.

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*Ppp6c^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ppp6c^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ppp6c^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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