Sclt1 | sodium channel and clathrin linker 1
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Vision/eye Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| polydactyly | 1 supporting dataset | Sclt1em1(IMPC)Tcp | homozygote | E18.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Sclt1em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| increased circulating triglyceride level | 1 supporting dataset | Sclt1em1(IMPC)Tcp | heterozygote | Early adult | 1.89x10-5 | ||
| abnormal eye morphology | 1 supporting dataset | Sclt1em1(IMPC)Tcp | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
Human diseases caused by Sclt1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Sclt1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Sclt1em1(IMPC)Tcp | Exon Deletion | | mouse |
| Sclt1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Sclt1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |