Mmachc | methylmalonic aciduria cblC type, with homocystinuria

GeneMGI:1914346Synonyms: 1810037K07Rik

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Embryo Growth/size/body region Limbs/digits/tail Vision/eye Respiratory system Craniofacial Mortality/aging Renal/urinary system

9 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

51Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal embryo size	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
pallor	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
polydactyly	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
facial cleft	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
microphthalmia	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	heterozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Mmachc^{tm1.1(NCOM)Mfgc}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mmachc.

Associated images

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Histopathology

There is no histopathology data found for Mmachc.

IMPC related publications

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External links

No external links available for Mmachc.

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*Mmachc^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell mouse
*Mmachc^{tm1.1(NCOM)Mfgc}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Mmachc^{tm299933(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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