Gatm | glycine amidinotransferase (L-arginine:glycine amidinotransferase)

GeneMGI:1914342Synonyms: 1810003P21Rik

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Nervous system Hematopoietic system Behavior/neurological Cardiovascular system

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	6 supporting datasets	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.92x10^-8
decreased food intake	1 supporting dataset	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.87x10^-7
decreased prepulse inhibition	3 supporting datasets	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.38x10^-6
abnormal sinus arrhythmia	1 supporting dataset	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.55x10^-25
decreased grip strength	4 supporting datasets	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.39x10^-23
thrombocytopenia	1 supporting dataset	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.23x10^-8
increased heart rate variability	1 supporting dataset	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.86x10^-24
decreased heart rate	1 supporting dataset	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.2x10^-7
cardiovascular system phenotype	1 supporting dataset	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.51x10^-21
prolonged QT interval	1 supporting dataset	Gatm^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.09x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gatm.

Associated images

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Histopathology

There is no histopathology data found for Gatm.

IMPC related publications

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External links

No external links available for Gatm.

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*Gatm^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Gatm^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gatm^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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