Polr3d | polymerase (RNA) III (DNA directed) polypeptide D
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Growth/size/body region Hematopoietic system Mortality/aging Renal/urinary system
13 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Polr3dem1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| enlarged urinary bladder | 1 supporting dataset | Polr3dem1(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Polr3dem1(IMPC)Tcp | heterozygote | Early adult | 9.9x10-11 | ||
| decreased circulating alkaline phosphatase level | 1 supporting dataset | Polr3dem1(IMPC)Tcp | heterozygote | Early adult | 1.89x10-5 | ||
| decreased mean platelet volume | 1 supporting dataset | Polr3dem1(IMPC)Tcp | heterozygote | Late adult | 3.91x10-5 | ||
| abnormal skin morphology | 2 supporting datasets | Polr3dem1(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Polr3dem1(IMPC)Tcp | homozygote | E9.5 | N/A * |
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External links
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| Polr3dem1(IMPC)Tcp | Exon Deletion | | mouse |
| Polr3dtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Polr3dtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |