Timm50 | translocase of inner mitochondrial membrane 50

GeneMGI:1913775Synonyms: TIM50L, 2810403L02Rik

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Vision/eye Skeleton Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

22Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased total body fat amount	2 supporting datasets	Timm50^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.44x10^-7
decreased bone mineral content	2 supporting datasets	Timm50^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.64x10^-8
decreased body length	1 supporting dataset	Timm50^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.88x10^-6
increased lean body mass	2 supporting datasets	Timm50^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.47x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Timm50^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Timm50^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.89x10^-13
abnormal retina outer nuclear layer morphology	1 supporting dataset	Timm50^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.94x10^-5
decreased total retina thickness	1 supporting dataset	Timm50^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.38x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Timm50^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
increased bone mineral density	1 supporting dataset	Timm50^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.05x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Timm50.

Associated images

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Histopathology

There is no histopathology data found for Timm50.

IMPC related publications

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External links

No external links available for Timm50.

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*Timm50^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Timm50^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Timm50^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Timm50^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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