Bbox1 | gamma-butyrobetaine hydroxylase 1

Physiological systems

23 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Embryo Growth/size/body region Nervous system Behavior/neurological Mortality/aging Cardiovascular system Craniofacial

15 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:76Adult tissues

83Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	2 supporting datasets	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	heterozygote	E18.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal forebrain morphology	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal hindbrain morphology	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal midbrain morphology	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
increased heart weight	1 supporting dataset	Bbox1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.85x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bbox1.

Associated images

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Histopathology

There is no histopathology data found for Bbox1.

IMPC related publications

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External links

No external links available for Bbox1.

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*Bbox1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Bbox1^em2(IMPC)Bay*		‌	mouse
*Bbox1^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Bbox1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Bbox1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Bbox1^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

My Genes