Ube3b | ubiquitin protein ligase E3B

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Cardiovascular system Craniofacial

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



abnormal iris morphology	1 supporting dataset	Ube3b^em1(IMPC)Bay	heterozygote	Early adult	6.87x10^-9
abnormal embryo size	1 supporting dataset	Ube3b^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Ube3b^{Gt(RRJ142)Byg}	homozygote	Early adult	N/A ^*
abnormal facial morphology	2 supporting datasets	Ube3b^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
decreased circulating cholesterol level	1 supporting dataset	Ube3b^{Gt(RRJ142)Byg}	homozygote	Early adult	1.62x10^-5
trunk curl	1 supporting dataset	Ube3b^{Gt(RRJ142)Byg}	heterozygote	Early adult	2.6x10^-5
increased cornea thickness	2 supporting datasets	Ube3b^em1(IMPC)Bay	heterozygote	Early adult	2.89x10^-55
decreased circulating LDL cholesterol level	1 supporting dataset	Ube3b^{Gt(RRJ142)Byg}	homozygote	Early adult	2.06x10^-6
eye hemorrhage	1 supporting dataset	Ube3b^em1(IMPC)Bay	heterozygote	Early adult	1.16x10^-9
preweaning lethality, complete penetrance	3 supporting datasets	Ube3b^em1(IMPC)Bay	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ube3b.

Associated images

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Histopathology

There is no histopathology data found for Ube3b.

IMPC related publications

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External links

No external links available for Ube3b.

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*Ube3b^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Ube3b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ube3b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Ube3b^{tm39371(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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