Srsf4 | serine and arginine-rich splicing factor 4

GeneMGI:1890577Synonyms: 5730499P16Rik, Sfrs4, +2 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Immune system Integument Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal coat/hair pigmentation	1 supporting dataset	Srsf4^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.98x10^-5
preweaning lethality, incomplete penetrance	2 supporting datasets	Srsf4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating creatinine level	1 supporting dataset	Srsf4^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.76x10^-6
abnormal coat/hair pigmentation	1 supporting dataset	Srsf4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.77x10^-5
abnormal tail movements	1 supporting dataset	Srsf4^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.92x10^-5
decreased hematocrit	1 supporting dataset	Srsf4^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.12x10^-7
increased IgE level	1 supporting dataset	Srsf4^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.72x10^-15

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Srsf4.

Associated images

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Histopathology

There is no histopathology data found for Srsf4.

IMPC related publications

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External links

No external links available for Srsf4.

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*Srsf4^{tm1.1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	es cell
*Srsf4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Srsf4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Srsf4^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell

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