Cdh23 | cadherin related 23 (otocadherin)

GeneMGI:1890219Synonyms: nmf181, bob, +7 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

9Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	3.37x10^-5
abnormal gait	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.03x10^-14
decreased circulating glucose level	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	7.18x10^-5
absent pinna reflex	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.05x10^-18
increased circulating sodium level	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	4.43x10^-6
impaired righting response	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.69x10^-14
trunk curl	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	7.25x10^-20
decreased fasting circulating glucose level	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.79x10^-15
increased circulating chloride level	1 supporting dataset	Cdh23^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.08x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cdh23.

Associated images

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Histopathology

There is no histopathology data found for Cdh23.

IMPC related publications

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External links

No external links available for Cdh23.

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*Cdh23^em1H*	Point Mutation	‌	mouse
*Cdh23^em2H*	Point Mutation	‌	mouse
*Cdh23^em3(IMPC)H*	Point Mutation	‌	mouse
*Cdh23^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cdh23^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cdh23^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Cdh23^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Cdh23^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cdh23^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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