Gnasas1 | GNAS antisense RNA 1

GeneMGI:1861674Synonyms: Gnas-as, Nespas

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal response to new environment1 supporting datasetGnasas1tm2.1JopheterozygoteEarly adult3.17x10-5 
decreased grip strength2 supporting datasetsGnasas1tm1JopheterozygoteEarly adult1.35x10-7 
abnormal startle reflex1 supporting datasetGnasas1tm2.1JopheterozygoteEarly adult3.54x10-5 
preweaning lethality, complete penetrance1 supporting datasetGnasas1tm1JophomozygoteEarly adultN/A * 
increased circulating glycerol level1 supporting datasetGnasas1tm2.1JopheterozygoteEarly adult2.22x10-5 
decreased hematocrit1 supporting datasetGnasas1tm1JopheterozygoteEarly adult1.68x10-5 
decreased circulating free fatty acids level1 supporting datasetGnasas1tm2.1JopheterozygoteEarly adult2.44x10-5 
abnormal startle reflex1 supporting datasetGnasas1tm1JopheterozygoteEarly adult1.23x10-6 
preweaning lethality, complete penetrance1 supporting datasetGnasas1tm2.1JophomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Gnasas1tm1JopReporter-tagged deletion allele (with selection cassette)mouse

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