Phgdh | 3-phosphoglycerate dehydrogenase

GeneMGI:1355330Synonyms: 3-PGDH, PGAD, +5 more

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system Craniofacial Mortality/aging

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

128Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



unresponsive to tactile stimuli	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	heterozygote	E18.5	N/A ^*
abnormal head shape	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	homozygote	E15.5	N/A ^*
abnormal vitelline vasculature morphology	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal embryo size	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal hindbrain morphology	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
decreased fluid intake	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.12x10^-5
abnormal embryo turning	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal eye morphology	1 supporting dataset	Phgdh^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Phgdh.

Associated images

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Histopathology

There is no histopathology data found for Phgdh.

IMPC related publications

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External links

No external links available for Phgdh.

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*Phgdh^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Phgdh^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Phgdh^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Phgdh^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Phgdh^{tm44754(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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