Aldh3a2 | aldehyde dehydrogenase family 3, subfamily A2

GeneMGI:1353452Synonyms: Ahd-3r, Ahd-3, +5 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system Behavior/neurological

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased startle reflex5 supporting datasetsAldh3a2tm1a(EUCOMM)WtsihomozygoteEarly adult3.77x10-29 
abnormal behavior2 supporting datasetsAldh3a2tm1a(EUCOMM)WtsihomozygoteEarly adult1.81x10-5 
decreased prepulse inhibition3 supporting datasetsAldh3a2tm1a(EUCOMM)WtsihomozygoteEarly adult7.56x10-6 
decreased circulating alkaline phosphatase level1 supporting datasetAldh3a2tm1a(EUCOMM)WtsihomozygoteEarly adult1.17x10-6 
decreased locomotor activity1 supporting datasetAldh3a2tm1a(EUCOMM)WtsihomozygoteEarly adult3.32x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Aldh3a2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
mouse
Aldh3a2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Aldh3a2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Aldh3a2tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell
Aldh3a2tm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell
Aldh3a2tm2(EGFP/cre/ERT2)WtsiReporter-tagged deletion allele (with selection cassette)es cell
mouse

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