Ndrg3 | N-myc downstream regulated gene 3

GeneMGI:1352499Synonyms: Ndr3, 4833415O14Rik

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Embryo Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased freezing behavior	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	heterozygote	Early adult	4.74x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Ndrg3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal neural tube morphology	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
small testis	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased circulating calcium level	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	heterozygote	Early adult	8.35x10^-5
abnormal eye morphology	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Ndrg3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ndrg3.

Associated images

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Histopathology

There is no histopathology data found for Ndrg3.

IMPC related publications

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External links

No external links available for Ndrg3.

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*Ndrg3^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ndrg3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ndrg3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ndrg3^{tm35448(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ndrg3^{tm356715(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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