Nr6a1 | nuclear receptor subfamily 6, group A, member 1

GeneMGI:1352459Synonyms: Gcnf, 1700113M01Rik, +1 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Cardiovascular system Craniofacial Mortality/aging

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



abnormal heart looping	1 supporting dataset	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
increased bone mineral density	1 supporting dataset	Nr6a1^Nr6a1	heterozygote	Early adult	3.85x10^-6
preweaning lethality, complete penetrance	3 supporting datasets	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
abnormal midbrain development	1 supporting dataset	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
abnormal heart morphology	1 supporting dataset	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
abnormal embryo size	1 supporting dataset	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
abnormal forebrain development	1 supporting dataset	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
abnormal optic vesicle formation	1 supporting dataset	Nr6a1^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nr6a1.

Associated images

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Histopathology

There is no histopathology data found for Nr6a1.

IMPC related publications

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External links

No external links available for Nr6a1.

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*Nr6a1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nr6a1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nr6a1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Nr6a1^{tm47175(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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