Ldb3 | LIM domain binding 3
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system
10 No significant impact
5 Not tested
Gene metrics:7Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
42Embryo tissues
| enlarged kidney | 1 supporting dataset | Ldb3tm2b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| increased basophil cell number | 1 supporting dataset | Ldb3tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.39x10-5 | ||
| increased large unstained cell number | 2 supporting datasets | Ldb3tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 6.19x10-6 | ||
| small seminal vesicle | 1 supporting dataset | Ldb3tm2b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| prolonged QRS complex duration | 1 supporting dataset | Ldb3tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.24x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Ldb3tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 3.35x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ldb3tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
Human diseases caused by Ldb3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ldb3.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Ldb3tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ldb3tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ldb3tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |