Drg2 | developmentally regulated GTP binding protein 2

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Nervous system Behavior/neurological Skeleton Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased body length	1 supporting dataset	Drg2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.13x10^-7
long tibia	1 supporting dataset	Drg2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.66x10^-5
abnormal locomotor activation	1 supporting dataset	Drg2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.01x10^-5
increased startle reflex	1 supporting dataset	Drg2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.92x10^-5
decreased circulating triglyceride level	1 supporting dataset	Drg2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.29x10^-5
decreased prepulse inhibition	1 supporting dataset	Drg2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.5x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Drg2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating phosphate level	1 supporting dataset	Drg2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.11x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Drg2.

Associated images

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Histopathology

There is no histopathology data found for Drg2.

IMPC related publications

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External links

No external links available for Drg2.

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*Drg2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Drg2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Drg2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Drg2^{tm291(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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