Lgr5 | leucine rich repeat containing G protein coupled receptor 5
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Immune system Growth/size/body region Digestive/alimentary Hematopoietic system Behavior/neurological Mortality/aging Craniofacial
12 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | homozygote | Early adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | heterozygote | E18.5 | N/A * | ||
| cleft palate | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | homozygote | E18.5 | N/A * | ||
| increased CD11b-high dendritic cell number | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | heterozygote | Early adult | 3.69x10-6 | ||
| no spontaneous movement | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | homozygote | E18.5 | N/A * | ||
| increased grip strength | 3 supporting datasets | Lgr5em1(IMPC)Kmpc | heterozygote | Early adult | 9.12x10-6 | ||
| increased CD8-positive, CD25-positive alpha-beta T cell number | 1 supporting dataset | Lgr5em1(IMPC)Kmpc | heterozygote | Early adult | 1.31x10-5 |
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External links
No external links available for Lgr5.
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| Lgr5em1(IMPC)Kmpc | Deletion | | mouse |
| Lgr5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Lgr5tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Lgr5tm374781(L1L2_GT2_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |