Parp1 | poly (ADP-ribose) polymerase family, member 1

GeneMGI:1340806Synonyms: PARP, Adprp, +4 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased prepulse inhibition	1 supporting dataset	Parp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.75x10^-6
decreased total retina thickness	2 supporting datasets	Parp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.39x10^-7
abnormal retina inner nuclear layer morphology	1 supporting dataset	Parp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.16x10^-5
decreased grip strength	3 supporting datasets	Parp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.3x10^-5
immune system phenotype	2 supporting datasets	Parp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.45x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Parp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Parp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Parp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.76x10^-7
decreased NK cell number	2 supporting datasets	Parp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.63x10^-7
microphthalmia	1 supporting dataset	Parp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Parp1.

Associated images

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Histopathology

There is no histopathology data found for Parp1.

IMPC related publications

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External links

No external links available for Parp1.

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*Parp1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Parp1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Parp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Parp1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Parp1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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