Uhrf1 | ubiquitin-like, containing PHD and RING finger domains, 1

GeneMGI:1338889Synonyms: ICBP90, Np95

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Immune system Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased NK cell number	1 supporting dataset	Uhrf1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.54x10^-6
abnormal retina pigmentation	2 supporting datasets	Uhrf1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.48x10^-7
abnormal gait	1 supporting dataset	Uhrf1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.52x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Uhrf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Uhrf1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.15x10^-5
decreased body weight	1 supporting dataset	Uhrf1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.72x10^-5
decreased mean corpuscular volume	1 supporting dataset	Uhrf1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.42x10^-5
abnormal eye morphology	1 supporting dataset	Uhrf1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.75x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Uhrf1.

Associated images

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Histopathology

There is no histopathology data found for Uhrf1.

IMPC related publications

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External links

No external links available for Uhrf1.

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*Uhrf1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Uhrf1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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