Gnb1l | guanine nucleotide binding protein (G protein), beta polypeptide 1-like

GeneMGI:1338057Synonyms: ESTM55, Wdr14, +2 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging Cardiovascular system

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal neural tube morphology	1 supporting dataset	Gnb1l^em1(IMPC)Tcp	heterozygote	E9.5	N/A ^*
abnormal embryo size	1 supporting dataset	Gnb1l^em1(IMPC)Tcp	heterozygote	E9.5	N/A ^*
abnormal retina blood vessel morphology	2 supporting datasets	Gnb1l^em1(IMPC)Tcp	heterozygote	Early adult	1.52x10^-6
abnormal midbrain development	1 supporting dataset	Gnb1l^em1(IMPC)Tcp	heterozygote	E9.5	N/A ^*
abnormal forebrain development	1 supporting dataset	Gnb1l^em1(IMPC)Tcp	heterozygote	E9.5	N/A ^*
abnormal hindbrain development	1 supporting dataset	Gnb1l^em1(IMPC)Tcp	heterozygote	E9.5	N/A ^*
abnormal retina vasculature morphology	1 supporting dataset	Gnb1l^em1(IMPC)Tcp	heterozygote	Early adult	2.42x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Gnb1l^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gnb1l.

Associated images

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Histopathology

There is no histopathology data found for Gnb1l.

IMPC related publications

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External links

No external links available for Gnb1l.

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*Gnb1l^em1(IMPC)Tcp*	Insertion, Intragenic deletion	‌	mouse
*Gnb1l^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gnb1l^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gnb1l^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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