Dclk1 | doublecortin-like kinase 1

GeneMGI:1330861Synonyms: Click-I, Dcl, +5 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Behavior/neurological

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased anti-nuclear antigen antibody level	4 supporting datasets	Dclk1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
decreased circulating magnesium level	1 supporting dataset	Dclk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.31x10^-6
increased anti-nuclear antigen antibody level	4 supporting datasets	Dclk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Dclk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.33x10^-5
increased grip strength	1 supporting dataset	Dclk1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.78x10^-6
increased grip strength	1 supporting dataset	Dclk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.61x10^-6
decreased body length	1 supporting dataset	Dclk1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.8x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dclk1.

Associated images

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Histopathology

There is no histopathology data found for Dclk1.

IMPC related publications

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External links

No external links available for Dclk1.

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*Dclk1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dclk1^{tm240457(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector
*Dclk1^{tm438463(L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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