Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a

GeneMGI:1314884Synonyms: TNF-alphaR1, CD120a, +13 more

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

4Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Allele:

Phy. System:

Life Stage:



decreased circulating calcium level	1 supporting dataset	Tnfrsf1a^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	7.71x10^-5
increased grip strength	2 supporting datasets	Tnfrsf1a^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	2.75x10^-5
increased basophil cell number	1 supporting dataset	Tnfrsf1a^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	1.56x10^-7
decreased neutrophil cell number	1 supporting dataset	Tnfrsf1a^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	2.83x10^-5
abnormal heart morphology	1 supporting dataset	Tnfrsf1a^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased lymphocyte cell number	3 supporting datasets	Tnfrsf1a^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	1.51x10^-10
increased neutrophil cell number	2 supporting datasets	Tnfrsf1a^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.18x10^-5
increased basophil cell number	1 supporting dataset	Tnfrsf1a^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	9.68x10^-6
increased large unstained cell number	1 supporting dataset	Tnfrsf1a^{tm2b(EUCOMM)Wtsi}	homozygote	Late adult	5.49x10^-5
increased effector memory CD8-positive, alpha-beta T cell number	1 supporting dataset	Tnfrsf1a^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.46x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tnfrsf1a.

Associated images

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Histopathology

There is no histopathology data found for Tnfrsf1a.

IMPC related publications

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External links

No external links available for Tnfrsf1a.

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*Tnfrsf1a^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Tnfrsf1a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Tnfrsf1a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Tnfrsf1a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Tnfrsf1a^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tnfrsf1a^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tnfrsf1a^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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