Psen1 | presenilin 1

GeneMGI:1202717Synonyms: PS-1, Ad3h, +3 more

Physiological systems

23 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Behavior/neurological Mortality/aging Cardiovascular system

18 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

10Associated diseases

Expression examined in:74Adult tissues

53Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal tail morphology	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
edema	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
abnormal limb morphology	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
abnormal limb morphology	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
edema	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
increased startle reflex	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.4x10^-5
abnormal tail morphology	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Psen1^{tm1.1(KOMP)Vlcg}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	4 supporting datasets	Psen1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Psen1.

Associated images

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Histopathology

There is no histopathology data found for Psen1.

IMPC related publications

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External links

No external links available for Psen1.

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*Psen1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Psen1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Psen1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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