Itch | itchy, E3 ubiquitin protein ligase

GeneMGI:1202301Synonyms: 6720481N21Rik, AIP4, +2 more

Physiological systems

21 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Digestive/alimentary Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial Renal/urinary system

8 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:39Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased basophil cell number	1 supporting dataset	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.71x10^-14
decreased bone mineral density	1 supporting dataset	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.46x10^-17
decreased circulating alkaline phosphatase level	1 supporting dataset	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.12x10^-28
abnormal bone structure	1 supporting dataset	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.1x10^-21
decreased mean corpuscular hemoglobin	1 supporting dataset	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.67x10^-17
decreased hemoglobin content	1 supporting dataset	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.68x10^-36
increased eosinophil cell number	2 supporting datasets	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.26x10^-62
enlarged kidney	1 supporting dataset	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.11x10^-34
decreased hematocrit	1 supporting dataset	Itch^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.53x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Itch.

Associated images

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Histopathology

There is no histopathology data found for Itch.

IMPC related publications

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External links

No external links available for Itch.

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*Itch^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Itch^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Itch^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Itch^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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