Sorl1 | sortilin-related receptor, LDLR class A repeats-containing
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Reproductive system Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system Craniofacial
13 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| enlarged seminal vesicle | 1 supporting dataset | Sorl1tm1b(EUCOMM)Wtsi | homozygote | Late adult | N/A * | ||
| increased heart rate | 1 supporting dataset | Sorl1tm1a(EUCOMM)Wtsi | homozygote | Late adult | 9.85x10-5 | ||
| abnormal gait | 1 supporting dataset | Sorl1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.76x10-7 | ||
| decreased prepulse inhibition | 1 supporting dataset | Sorl1tm1a(EUCOMM)Wtsi | homozygote | Late adult | 2.84x10-5 | ||
| decreased startle reflex | 1 supporting dataset | Sorl1tm1a(EUCOMM)Wtsi | homozygote | Late adult | 5.26x10-7 | ||
| abnormal snout morphology | 1 supporting dataset | Sorl1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.01x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Sorl1tm1b(EUCOMM)Wtsi | homozygote | Late adult | 8.9x10-12 |
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External links
No external links available for Sorl1.
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| Sorl1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Sorl1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Sorl1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | es cell |