Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit)

GeneMGI:1197514Synonyms: DNA polymerase epsilon small subunit

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Embryo Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system Mortality/aging

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal heart morphology	1 supporting dataset	Pole2^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
abnormal skin morphology	1 supporting dataset	Pole2^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
small heart	2 supporting datasets	Pole2^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
impaired glucose tolerance	1 supporting dataset	Pole2^em1(IMPC)Mbp	heterozygote	Late adult	6.35x10^-6
enlarged spleen	1 supporting dataset	Pole2^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Pole2^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Pole2^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Pole2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal embryo turning	1 supporting dataset	Pole2^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
abnormal spleen morphology	2 supporting datasets	Pole2^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pole2.

Associated images

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Histopathology

There is no histopathology data found for Pole2.

IMPC related publications

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External links

No external links available for Pole2.

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*Pole2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Pole2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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