Rasa3 | RAS p21 protein activator 3

GeneMGI:1197013Synonyms: R-Ras gap, hlb381, +4 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Nervous system Behavior/neurological Cardiovascular system Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

46Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hemorrhage	1 supporting dataset	Rasa3^tm1b(KOMP)J	homozygote	E12.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Rasa3^tm1b(KOMP)J	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Rasa3^tm1b(KOMP)J	homozygote	Early adult	N/A ^*
decreased circulating glucose level	1 supporting dataset	Rasa3^tm1b(KOMP)J	heterozygote	Early adult	9.6x10^-5
abnormal forebrain morphology	1 supporting dataset	Rasa3^tm1b(KOMP)J	homozygote	E12.5	N/A ^*
increased heart weight	1 supporting dataset	Rasa3^tm1b(KOMP)J	heterozygote	Early adult	4.33x10^-7
abnormal sleep behavior	1 supporting dataset	Rasa3^tm1b(KOMP)J	heterozygote	Early adult	6.19x10^-5
abnormal midbrain morphology	1 supporting dataset	Rasa3^tm1b(KOMP)J	homozygote	E12.5	N/A ^*
decreased exploration in new environment	1 supporting dataset	Rasa3^tm1b(KOMP)J	heterozygote	Early adult	5.53x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rasa3.

Associated images

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Histopathology

There is no histopathology data found for Rasa3.

IMPC related publications

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External links

No external links available for Rasa3.

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*Rasa3^tm1a(KOMP)J*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rasa3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Rasa3^tm1b(KOMP)J*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rasa3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Rasa3^{tm47947(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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