Rbbp4 | retinoblastoma binding protein 4, chromatin remodeling factor

GeneMGI:1194912Synonyms: CAF-1 p48 subunit, RBAP48

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Embryo Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Mortality/aging Cardiovascular system Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal eye morphology	2 supporting datasets	Rbbp4^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal liver morphology	2 supporting datasets	Rbbp4^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
spina bifida	1 supporting dataset	Rbbp4^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
decreased exploration in new environment	1 supporting dataset	Rbbp4^em1(IMPC)Mbp	heterozygote	Early adult	3.71x10^-8
preweaning lethality, complete penetrance	3 supporting datasets	Rbbp4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased bone mineral content	1 supporting dataset	Rbbp4^em1(IMPC)Mbp	heterozygote	Early adult	2.32x10^-6
embryonic lethality prior to organogenesis	1 supporting dataset	Rbbp4^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Rbbp4^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Rbbp4^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal gallbladder morphology	1 supporting dataset	Rbbp4^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rbbp4.

Associated images

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Histopathology

There is no histopathology data found for Rbbp4.

IMPC related publications

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External links

No external links available for Rbbp4.

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*Rbbp4^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Rbbp4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Rbbp4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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