Med1 | mediator complex subunit 1

GeneMGI:1100846Synonyms: DRIP205, Pparbp, +5 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Integument Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to tooth bud stage	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
abnormal placenta size	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
abnormal embryo size	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
pallor	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
small superior vagus ganglion	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
hydrometra	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
pale yolk sac	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
enlarged uterus	1 supporting dataset	Med1^{tm3b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Med1.

Associated images

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Histopathology

There is no histopathology data found for Med1.

IMPC related publications

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External links

No external links available for Med1.

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*Med1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Med1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Med1^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Med1^{tm3b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Med1^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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