Fgf10 | fibroblast growth factor 10

GeneMGI:1099809Synonyms: Gsfaey17, FGF-10, +1 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

4Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



narrow eye opening	1 supporting dataset	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.69x10^-23
decreased thigmotaxis	2 supporting datasets	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.57x10^-6
increased circulating cholesterol level	1 supporting dataset	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.01x10^-5
impaired pupillary reflex	1 supporting dataset	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.49x10^-11
abnormal behavior	1 supporting dataset	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.57x10^-6
increased total body fat amount	2 supporting datasets	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.96x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3x10^-5
abnormal cornea morphology	1 supporting dataset	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.53x10^-12
preweaning lethality, complete penetrance	1 supporting dataset	Fgf10^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
cornea opacity	1 supporting dataset	Fgf10^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.3x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fgf10.

Associated images

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Histopathology

There is no histopathology data found for Fgf10.

IMPC related publications

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External links

No external links available for Fgf10.

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*Fgf10^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Fgf10^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Fgf10^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fgf10^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Fgf10^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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