Cdk12 | cyclin dependent kinase 12

GeneMGI:1098802Synonyms: 1810022J16Rik, Crkrs, +2 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal urinary bladder morphology	1 supporting dataset	Cdk12^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Cdk12^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Cdk12^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
decreased erythrocyte cell number	1 supporting dataset	Cdk12^em1(IMPC)Tcp	heterozygote	Early adult	1.03x10^-9
preweaning lethality, complete penetrance	3 supporting datasets	Cdk12^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Cdk12^em1(IMPC)Tcp	homozygote	E15.5	N/A ^*
decreased exploration in new environment	1 supporting dataset	Cdk12^em1(IMPC)Tcp	heterozygote	Late adult	9.81x10^-5
decreased hematocrit	1 supporting dataset	Cdk12^em1(IMPC)Tcp	heterozygote	Early adult	4.72x10^-12
increased spleen weight	1 supporting dataset	Cdk12^em1(IMPC)Tcp	heterozygote	Early adult	2.04x10^-7
increased red blood cell distribution width	1 supporting dataset	Cdk12^em1(IMPC)Tcp	heterozygote	Early adult	6.5x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cdk12.

Associated images

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Histopathology

There is no histopathology data found for Cdk12.

IMPC related publications

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External links

No external links available for Cdk12.

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*Cdk12^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Cdk12^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cdk12^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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