Aak1 | AP2 associated kinase 1

GeneMGI:1098687Synonyms: D6Ertd245e, 5530400K14Rik

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Hearing/vestibular/ear Nervous system Vision/eye Behavior/neurological Skeleton Cardiovascular system Mortality/aging

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal contextual conditioning behavior	4 supporting datasets	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.39x10^-5
short tibia	2 supporting datasets	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.7x10^-14
increased circulating alkaline phosphatase level	1 supporting dataset	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.27x10^-11
preweaning lethality, incomplete penetrance	1 supporting dataset	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	4 supporting datasets	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.27x10^-16
decreased circulating total protein level	1 supporting dataset	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.2x10^-7
abnormal bone structure	1 supporting dataset	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.8x10^-10
decreased circulating cholesterol level	1 supporting dataset	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.63x10^-5
impaired glucose tolerance	1 supporting dataset	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.41x10^-5
hyperactivity	2 supporting datasets	Aak1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.54x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aak1.

Associated images

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Histopathology

There is no histopathology data found for Aak1.

IMPC related publications

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External links

No external links available for Aak1.

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*Aak1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Aak1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Aak1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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