Nhp2 | NHP2 ribonucleoprotein

GeneMGI:1098547Synonyms: H/ACA small nucleolar RNPs, Nola2, +3 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Mortality/aging

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Nhp2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Nhp2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	7.05x10^-5
increased body length	1 supporting dataset	Nhp2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	4.95x10^-7
decreased circulating fructosamine level	1 supporting dataset	Nhp2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.79x10^-5
decreased total body fat amount	2 supporting datasets	Nhp2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.44x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nhp2.

Associated images

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Histopathology

There is no histopathology data found for Nhp2.

IMPC related publications

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External links

No external links available for Nhp2.

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*Nhp2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nhp2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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