Irf4 | interferon regulatory factor 4

GeneMGI:1096873Synonyms: Spip, IRF-4

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Behavior/neurological

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



enlarged lymph nodes	2 supporting datasets	Irf4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Irf4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Irf4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased lymphocyte cell number	1 supporting dataset	Irf4^em1(IMPC)Mbp	homozygote	Early adult	2.82x10^-6
abnormal lymph node morphology	2 supporting datasets	Irf4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Irf4^em1(IMPC)Mbp	homozygote	Early adult	1.59x10^-5
abnormal thymus morphology	1 supporting dataset	Irf4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Irf4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased neutrophil cell number	1 supporting dataset	Irf4^em1(IMPC)Mbp	homozygote	Early adult	5.65x10^-6
abnormal startle reflex	1 supporting dataset	Irf4^em1(IMPC)Mbp	homozygote	Middle aged adult	9.37x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Irf4.

Associated images

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Histopathology

There is no histopathology data found for Irf4.

IMPC related publications

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External links

No external links available for Irf4.

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*Irf4^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Irf4^{tm301408(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Irf4^{tm38920(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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