Psen2 | presenilin 2

GeneMGI:109284Synonyms: Ad4h, PS2, +2 more

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Cardiovascular system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal thymus morphology	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.52x10^-5
abnormal digit morphology	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.99x10^-8
abnormal heart morphology	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
hydrocephaly	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.49x10^-5
abnormal brain morphology	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Psen2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Psen2.

Associated images

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Histopathology

There is no histopathology data found for Psen2.

IMPC related publications

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External links

No external links available for Psen2.

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*Psen2^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Psen2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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