Fzd3 | frizzled class receptor 3

GeneMGI:108476Synonyms: Fz3, D930050A07Rik

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Behavior/neurological Skeleton Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Fzd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased grip strength	1 supporting dataset	Fzd3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.6x10^-5
impaired glucose tolerance	1 supporting dataset	Fzd3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.82x10^-8
decreased bone mineral content	1 supporting dataset	Fzd3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.19x10^-5
increased total body fat amount	1 supporting dataset	Fzd3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.3x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fzd3.

Associated images

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Histopathology

There is no histopathology data found for Fzd3.

IMPC related publications

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External links

No external links available for Fzd3.

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*Fzd3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Fzd3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fzd3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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