Nfe2l2 | nuclear factor, erythroid derived 2, like 2

GeneMGI:108420Synonyms: Nrf2

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Skeleton Craniofacial

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal lymph node morphology	2 supporting datasets	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.53x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.72x10^-8
enlarged lymph nodes	1 supporting dataset	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	2 supporting datasets	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.26x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.86x10^-6
increased circulating lactate dehydrogenase level	1 supporting dataset	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.72x10^-5
abnormal thymus morphology	1 supporting dataset	Nfe2l2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nfe2l2.

Associated images

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Histopathology

There is no histopathology data found for Nfe2l2.

IMPC related publications

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External links

No external links available for Nfe2l2.

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*Nfe2l2^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Nfe2l2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Nfe2l2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Nfe2l2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Nfe2l2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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