Phex | phosphate regulating endopeptidase homolog, X-linked

GeneMGI:107489Synonyms: HPDR1

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Behavior/neurological Skeleton

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal body size	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	5.95x10^-6
abnormal tibia morphology	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	5.74x10^-11
decreased circulating amylase level	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	1.08x10^-8
decreased blood urea nitrogen level	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	6.65x10^-9
increased circulating alkaline phosphatase level	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	4.78x10^-14
abnormal bone mineralization	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	1.11x10^-9
decreased circulating phosphate level	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	4.45x10^-8
decreased body weight	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	4.39x10^-8
abnormal joint morphology	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	5.74x10^-11
abnormal vertebral arch morphology	1 supporting dataset	Phex^{not yet available}	homozygote	Early adult	4.04x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Phex.

Associated images

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Histopathology

There is no histopathology data found for Phex.

IMPC related publications

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External links

No external links available for Phex.

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*Phex^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Phex^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Phex^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Phex^{tm295268(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Phex^{tm41138(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Phex^{tm41138(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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