Myo6 | myosin VI

GeneMGI:104785Synonyms: Tlc, rsv, +1 more

Physiological systems

21 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system

8 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:38Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



abnormal gait	1 supporting dataset	Myo6^em1(IMPC)Tcp	homozygote	Early adult	1.81x10^-11
hyperactivity	9 supporting datasets	Myo6^em1(IMPC)Tcp	homozygote	Early adult	7.4x10^-158
abnormal sternum morphology	1 supporting dataset	Myo6^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
prolonged PR interval	1 supporting dataset	Myo6^em1(IMPC)Tcp	homozygote	Early adult	4.78x10^-6
hyperactivity	1 supporting dataset	Myo6^Tlc	heterozygote	Early adult	2.77x10^-11
abnormal auditory brainstem response	4 supporting datasets	Myo6^em1(IMPC)Tcp	homozygote	Early adult	1.61x10^-6
decreased prepulse inhibition	7 supporting datasets	Myo6^em1(IMPC)Tcp	homozygote	Early adult	1.15x10^-72
decreased circulating triglyceride level	1 supporting dataset	Myo6^Tlc	heterozygote	Early adult	8.59x10^-7
decreased total body fat amount	1 supporting dataset	Myo6^em1(IMPC)Tcp	homozygote	Early adult	6.83x10^-5
abnormal startle reflex	1 supporting dataset	Myo6^em1(IMPC)Tcp	homozygote	Early adult	2.32x10^-16

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Myo6.

Associated images

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Histopathology

There is no histopathology data found for Myo6.

IMPC related publications

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External links

No external links available for Myo6.

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*Myo6^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Myo6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Myo6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Myo6^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	es cell
*Myo6^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Myo6^{tm40489(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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