Col4a3 | collagen, type IV, alpha 3

GeneMGI:104688Synonyms: alpha3(IV), tumstatin

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Renal/urinary system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

7Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased basophil cell number	1 supporting dataset	Col4a3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.98x10^-5
decreased hemoglobin content	1 supporting dataset	Col4a3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.24x10^-8
increased neutrophil cell number	2 supporting datasets	Col4a3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.09x10^-8
decreased lymphocyte cell number	1 supporting dataset	Col4a3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.88x10^-8
increased kidney weight	1 supporting dataset	Col4a3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.46x10^-18
increased large unstained cell number	1 supporting dataset	Col4a3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.12x10^-5
decreased circulating amylase level	1 supporting dataset	Col4a3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.33x10^-5
irregularly shaped pupil	1 supporting dataset	Col4a3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.4x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Col4a3.

Associated images

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Histopathology

There is no histopathology data found for Col4a3.

IMPC related publications

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External links

No external links available for Col4a3.

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*Col4a3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Col4a3^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Col4a3^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Col4a3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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