Hgs | HGF-regulated tyrosine kinase substrate

GeneMGI:104681Synonyms: tn, Hrs

Physiological systems

23 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Behavior/neurological Mortality/aging

21 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetHgstm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
preweaning lethality, complete penetrance1 supporting datasetHgstm1a(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal behavior2 supporting datasetsHgstm1a(EUCOMM)WtsiheterozygoteEarly adult2.61x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hgstm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Hgstm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Hgstm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Hgstm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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