Atp2b1 | ATPase, Ca++ transporting, plasma membrane 1

GeneMGI:104653Synonyms: E130111D10Rik, PMCA1, +1 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Integument Hearing/vestibular/ear Mortality/aging

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

30Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	1 supporting dataset	Atp2b1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Atp2b1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
absent vibrissae	1 supporting dataset	Atp2b1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.29x10^-6
abnormal epididymis morphology	1 supporting dataset	Atp2b1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
enlarged epididymis	1 supporting dataset	Atp2b1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal vibrissa morphology	1 supporting dataset	Atp2b1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.16x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Atp2b1^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal auditory brainstem response	1 supporting dataset	Atp2b1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.73x10^-6
decreased circulating calcium level	1 supporting dataset	Atp2b1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.3x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp2b1.

Associated images

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Histopathology

There is no histopathology data found for Atp2b1.

IMPC related publications

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External links

No external links available for Atp2b1.

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*Atp2b1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Atp2b1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Atp2b1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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