Cdkn1a | cyclin dependent kinase inhibitor 1A

GeneMGI:104556Synonyms: Cdkn1, SDI1, +9 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system

16 No significant impact

3 Not tested

Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

small testis1 supporting datasetCdkn1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal testis morphology1 supporting datasetCdkn1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
enlarged epididymis1 supporting datasetCdkn1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal epididymis morphology1 supporting datasetCdkn1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
enlarged spleen1 supporting datasetCdkn1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal spleen morphology1 supporting datasetCdkn1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cdkn1aem1(IMPC)Cnrmmouse
Cdkn1aem2(IMPC)CnrmDeletionmouse
Cdkn1atm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
mouse
Cdkn1atm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Cdkn1atm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell

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