Rab19 | RAB19, member RAS oncogene family

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



cornea opacity	1 supporting dataset	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.15x10^-5
abnormal contextual conditioning behavior	2 supporting datasets	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.41x10^-5
increased eosinophil cell number	1 supporting dataset	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.48x10^-5
increased heart weight	1 supporting dataset	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1x10^-9
increased cornea thickness	1 supporting dataset	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.99x10^-5
persistence of hyaloid vascular system	1 supporting dataset	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.2x10^-5
decreased large unstained cell number	2 supporting datasets	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.43x10^-8
abnormal cornea morphology	1 supporting dataset	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.31x10^-5
decreased circulating calcium level	1 supporting dataset	Rab19^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.88x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rab19.

Associated images

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Histopathology

There is no histopathology data found for Rab19.

IMPC related publications

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External links

No external links available for Rab19.

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*Rab19^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Rab19^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rab19^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rab19^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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