Ube2a | ubiquitin-conjugating enzyme E2A
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system
11 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:98Adult tissues
50Embryo tissues
| decreased locomotor activity | 1 supporting dataset | Ube2atm1.1(KOMP)Vlcg | homozygote | Early adult | 7.18x10-5 | ||
| female infertility | 1 supporting dataset | Ube2atm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| hyperactivity | 1 supporting dataset | Ube2atm1.1(KOMP)Vlcg | hemizygote | Early adult | 8.35x10-5 | ||
| increased heart weight | 1 supporting dataset | Ube2atm1.1(KOMP)Vlcg | homozygote | Early adult | 5.25x10-6 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Ube2atm1.1(KOMP)Vlcg | homozygote | Early adult | 1.99x10-9 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Ube2atm1.1(KOMP)Vlcg | hemizygote | Early adult | 6.71x10-5 | ||
| increased startle reflex | 1 supporting dataset | Ube2atm1.1(KOMP)Vlcg | homozygote | Early adult | 6.44x10-8 | ||
| decreased grip strength | 1 supporting dataset | Ube2atm1.1(KOMP)Vlcg | homozygote | Early adult | 6.63x10-7 |
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External links
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| Ube2atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | es cell mouse |
| Ube2atm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Ube2atm88303(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |